Endocrine consequences of childhood cancer treatment in adult life
Abstract
With an ever increasing adult population of childhood cancer survivors there is a need to focus on the late effects of cancer therapy. It is essential that after discharge from the paediatric oncologists the patients are not lost from the health system but are under continued surveillance with access to the appropriate physicians. Endocrine and metabolic consequences may impact on a patient's life both soon after cancer treatment and also for many years in the future. The purpose of this article is to explore the following potential problems: growth hormone deficiency and replacement in adulthood, cardiovascular risk factors, osteopenia, thyroid problems, gonadal and uterine damage resulting in infertility, sex steroid deficiency and adverse reproductive outcome.
Keywords: child, neoplasms, growth hormone, cardiovascular risk, bone, thyroid, gonad, uterus, pregnancy
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- f1 Correspondence to: SMS. E-mail: stephen.m.shalet@man.ac.uk
PII: S0957-5839(01)90209-X
doi:10.1054/cupe.2001.0209
© 2001 Harcourt Publishers Ltd. All rights reserved.
