Current Paediatrics
Volume 11, Issue 6 , Pages 458-464, December 2001

Applied physiology: immune competence

  • A.R. Gennery (Specialist Registrar in Paediatric Immunology and Infectious Diseases)

      Affiliations

    • ,
  • A.J. Cant (Consultant Paediatrician (Immunology and Infectious Diseases))

Department of Paediatric Immunology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK

Abstract 

The immune system has evolved in order to prevent invasion by foreign organisms. This review outlines the principles and mechanisms of innate and acquired immunity, explaining each aspect of the response and how innate and acquired systems interact. The effects of deficiency in particular components are illustrated with reference to specific immunodeficiencies.

Keywords: innate immunity, acquired immunity, antibody diversity, immunodeficiency

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  • f1 Correspondence to ARG: Tel.: +0191-273-8811, Ext 22669; Fax: +0191-273-0183; E-mail: argennery@aol.com

PII: S0957-5839(01)90235-0

doi:10.1054/cupe.2001.0235

Current Paediatrics
Volume 11, Issue 6 , Pages 458-464, December 2001

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