Current Paediatrics
Volume 12, Issue 3 , Pages 191-198, June 2002

Understanding neurodegenerative disorders

Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK

Abstract 

The clinical features that suggest a neurodegenerative process are first discussed, then frameworks for conceptualizing the disorders and constructing a differential diagnosis. The characteristic clinical features and the focused investigation of two groups of disorders are discussed: leukoencephalopathies and the neuronal ceroid lipofuscinoses. These are exemplars for the investigation of white and grey matter disorders, respectively. Lastly, the gangliosidoses and mucopolysaccharidoses are briefly discussed. These four groups of disorders constitute the most common neurodegenerative disorders in the United Kingdom.

Keywords: heredodegenerative disorders, nervous system, paediatrics, leukodystrophy, neuronal ceroid lipofuscinosis, gangliosidoses, mucopolysaccharidosis

No full text is available. To read the body of this article, please view the PDF online.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 10.00 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 
  • f1 Correspondence to RS. Tel.: +44 (0)20 7837 7618; Fax: +44 (0)20 7833 9469; E-mail: r.surtees@ich.ucl.ac.uk

PII: S0957-5839(01)90283-0

doi:10.1054/cupe.2001.0283

Current Paediatrics
Volume 12, Issue 3 , Pages 191-198, June 2002

Article Tools