The management of immune thrombocytopenic purpura

Abstract 

The most common cause of thrombocytopenia in childhood is immune. The diagnosis must be carefully considered, as there are no specific diagnostic tests. Most children have an acute disease with spontaneous remission within a few weeks. Although the platelet count may be very low, bleeding symptoms are rarely severe, and most often restricted to the skin and mucous membranes. Most children do not require active treatment, but can be managed with good advice, ongoing support and a 24-h contact point. Children with significant bleeding problems may be treated with oral steroids, reserving intravenous immunoglobulin for emergencies or to cover injuries and surgery. About 20% of children continue with thrombocytopenia beyond 6 months (chronic ITP), but expectant management can continue, treatment is rarely required. Splenectomy is rarely required and should be reserved for the very rare child with serious bleeding persisting beyond 6 or 12 months.

Keywords: thrombocytopenia, autoimmune thrombocytopenic purpura, child, haemorrhagic disorders, thrombocytopenia + therapy

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• f1 Correspondence to: PB-M. Tel./Fax: +44 (0)151 252 5073; E-mail: p.h.boltonmaggs@liv.ac.uk