Current Paediatrics
Volume 13, Issue 7 , Pages 487-495, December 2003

Renal tubular disorders

  • Jo Dehoorne

      Affiliations

    • Clinical Fellow in Paediatric Nephrology, UK
    • ,
  • William van’t Hoff

      Affiliations

    • Consultant Paediatric Nephrologist, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    • Corresponding Author InformationCorrespondence to: WVH. Tel.: +44 (0)20 7405 9200 (ext 5583)

Abstract 

Renal tubular disorders in childhood are rare, but, when present, may produce profound electrolyte and volume disturbances. Children with hereditary tubular dysfunction commonly present in the first year of life with failure to thrive and other non-specific symptoms. Biochemical analysis of both serum and urine, together with clinical history and examination, remain fundamental for their diagnosis, whilst localization of the renal tubular defect to the proximal or distal nephron is necessary for understanding of the underlying pathophysiology and appropriate management. During recent years, important new information concerning diagnosis and treatment of selective tubular disorders has been acquired.

Keywords:  renal tubular disorders, childhood, diagnostic approach

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PII: S0957-5839(03)00110-6

doi:10.1016/j.cupe.2003.08.013

Current Paediatrics
Volume 13, Issue 7 , Pages 487-495, December 2003

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