Current Paediatrics
Volume 13, Issue 1 , Pages 47-52, February 2003

Applied physiology: understanding shock

Birmingham Children's Hospital, Steelhouse Lane, Birmingham, West Midlands, B4 6NH, UK

Article Outline

Abstract 

The primary function of the cardiovascular system is to maintain an adequate delivery of oxygen to the tissues to ensure the continued production of ATP via oxidative phosphorylation. Oxygen delivery is primarily dependent on cardiac function and is therefore sensitive to changes in myocardial contractility, preload and afterload. Matching oxygen delivery to metabolic activity requires, however, circulatory adjustments and normal transfer kinetics. This article will discuss the regulation and defence of cardiac output and oxygen delivery in health and in shock.

Keywords: cardiac output, oxygen delivery, sympathetic activity, tumour necrosis factor-alpha, nitric oxide

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References 

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    FURTHER READING
  1. Bartlett RH. Critical Care Physiology. Boston: Brown; 1996;
  2. Edwards JD, Shoemaker WC, Vincent JL. Oxygen Transport: Principles and Practice. London: W B Saunders; 1993;
  3. Guyton AC, Jones CE, Coleman TG. Cardiac Output and its Regulation. Philadelphia: WB Saunders; 1993;
  • f1 Correspondence to GM. Tel: +44 (0) 121 333 9652; Fax: +44 (0) 121 333 9651; E-mail: gcmor_1999@yahoo.co.uk

PII: S0957-5839(03)90408-8

doi:10.1054/cupe.2003.0408

Current Paediatrics
Volume 13, Issue 1 , Pages 47-52, February 2003

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