Current Paediatrics
Volume 15, Issue 1 , Pages 40-43, February 2005

Disorders of the red cell membrane

  • D. Webb

      Affiliations

    • Corresponding Author InformationTel.: +442074059200.

Haematology/Oncology Department, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London WC1N 3JH, UK

Summary 

Red cell membrane defects are a common cause of haemolytic anaemia—hereditary spherocytosis (HS) alone affects between 1 in 2500 and 1 in 5000 individuals and are due to defects in either the quality or quantity of the proteins of the cytoskeleton. They present a heterogeneous clinical picture varying from severe transfusion-dependent anaemia to an incidental finding in completely well individuals. In this review, the author will concentrate on two conditions: HS and elliptocytosis.

Keywords: Red cell, Membrane defects, Hereditary spherocytosis, Haemolytic anaemia, Children

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PII: S0957-5839(04)00154-X

doi:10.1016/j.cupe.2004.10.006

Current Paediatrics
Volume 15, Issue 1 , Pages 40-43, February 2005

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