Henoch–Schonlein purpura

Summary 

This review summarises the evidence from the latest published research on the epidemiology, aetiology, pathophysiology, clinical manifestations, treatment, and prognosis of Henoch–Schonlein purpura (HSP). Analysis of the literature indicates the importance of genetic and infectious aetiologic considerations in the development of HSP. And, within the last year, multiple inflammatory markers have been studied in association with the disease. Although, the common complaints associated with HSP are well known, the disease can also be associated with sequalae in multiple organ systems, as well as vasculitis throughout the body. No consensus has yet been agreed upon regarding treatment methodology of disease complications, but prognostic studies have determined that 6 months is appropriate in which to follow-up children to monitor for renal complications. Recent literature indicates the continued interest in defining the aetiology, complete clinical manifestations, treatment options and prognostic markers of HSP and the complications from the disease.

Keywords: Henoch–Schonlein purpura, Vasculitis, Nephritis